The 38-year-old has teamed up with Betfair to undertake the 'Defender to Contender' challenge, which is reportedly expected to be filmed for a TV documentary series.
After the news was announced, Neville contacted Ferdinand on Twitter, joking that the former footballer will need his ex-defensive partner Nemanja Vidic to help him.
The Sky Sports pundit wrote: "Hey @rioferdy5 when you're boxing does Vidic come in and take the punches whilst you cover round the back with me?"
Ferdinand responded by saying: "Vida did take some hits for us. He might have to come in my corner! Some1 that can take bit responsibility... will leave you out @GNev2."
The centre-back retired from football in 2015.