The two clubs meet in the last eight of the competition, with the cup the last opportunity for Antonio Conte to clinch silverware this season following the Blues' Champions League exit against Barcelona.
Puel told reporters in a press conference that the game presents an "exciting challenge" for the fans at the King Power Stadium.
"Yes the pressure is on Chelsea," the manager said. "It is the last chance for them to win a trophy. I think for us it is not just a normal game also. The players wait for these games with desire and without pressure because this team is favourite, but we have good attributes also and we can cause them problems.
"I hope all the big important games are to come, of course. We will see. I don't know.Of course all the games we can play are big. It is a decisive game, more important I don't know. It is a good opportunity at home, a chance to see perhaps the semi-finals.
"For Chelsea it is the same, the last opportunity to win something this season. It is a good challenge, an exciting challenge to play a big team in our stadium in front of our fans."
Chelsea beat Leicester at this stage of the FA Cup in 2012, with the West London outfit going on to lift the trophy at Wembley against Liverpool.