Can has acknowledged that United will be tough opponents at Anfield, but the German international has outlined ways in which the home side can get the better of Jose Mourinho's outfit.
The 23-year-old told the club's official website: "It will be a very, very tough game because Manchester United have done very well this season so far. But we know we are strong too and we are really looking forward to the game.
"We have to be hard in the tackles, we have to try to dominate the game and score the goals when we create chances. We will see what happens.
"It's always special to play at Anfield and now against Manchester United after a few weeks of not playing at Anfield. We are really excited and looking forward to the game and to play at Anfield again."
Can will be hoping to be recalled to the starting lineup after dropping to the bench for the 1-1 draw with Newcastle United.