Will Grigg scored his seventh FA Cup goal of the season to condemn 10-man Manchester City to fifth-round heartache and send Wigan Athletic into the quarter-finals courtesy of a 1-0 victory at the DW Stadium this evening.
City had full-back Fabian Delph controversially sent off in the first half, before being undone by a piece of counter-attacking brilliance from Grigg, whose late goal put an end to Pep Guardiola's quadruple hopes.
Victory for the Latics sees the League One side build on two previous back-to-back FA Cup wins over the Sky Blues, who were memorably beaten by Wigan in the 2013 final.
The Latics were able to cause problems of their own in the early stages, though, as a ball into the middle was poorly dealt with by Danilo, although Gary Roberts could not quite adjust his feet in time to test Claudio Bravo.
Grigg's industry was admirable in the first half and he soon profited from more complacency from Danilo, allowing the frontman to steal possession and lash a testing effort into the side-netting.
Wigan were forced to change their plans after Nick Powell was forced off through injury, leading to a period of increased dominance from Guardiola's charges. First Aymeric Laporte fluffed his lines just a few yards out from goal, before Fernandinho blazed over from close range after a smart knockdown from John Stones.
The home side continued to frustrate City going into the break and they were perhaps rewarded with a moment of controversy just before the whistle, when Fabian Delph was given a straight red card for a hefty challenge on Max Power.
At first it looked as though referee Anthony Taylor had decided to take a yellow from his pocket, only to draw a red for the full-back moments later.
The incident left Guardiola irked and he carried his protestations down into the tunnel at the break, as the Spaniard entered into an animated exchange with Latics boss Paul Cook.
Wigan approached the second period with similar industry to the first and for a while they kept City at bay, until Guardiola decided to introduce Kevin De Bruyne 25 minutes from time.
The Belgian appeared to have changed the contest instantly and he almost played Aguero in for an opener, only for the frontman to control poorly and see his eventual shot saved at the second attempt.
City continued to control possession despite being a man down, but that all changed 11 minutes from time, when Grigg broke away from Kyle Walker and kept his composure to bend a memorable finish beyond Bravo and hand the Latics the lead.
For all of City's best efforts to force a replay in the dying embers, Cook's charges held firm to take their FA Cup tally against the Sky Blues to three wins on the bounce.
The Latics will now face Southampton in the quarter-final stages with the hope of claiming their fourth Premier League scalp of the tournament.
WIGAN ATHLETIC: Walton; Byrne, Dunkley, Burn, Elder; Massey (Colclough '77), Power, Perkins; Powell (Fulton '27), Roberts (Jacobs '55); Grigg
MANCHESTER CITY: Bravo; Danilo, Stones, Laporte, Delph; Gundogan, Fernandinho, Silva (De Bruyne '65); Sane (Walker '46), Bernardo, Aguero